Linker, Spacer, PEGylations
| 【Numbering】BK2021071408 | 【CAS】CAS | ||
| 【Item No.】 | 【specification】 | ||
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The common pegylation is polyethylene glycol (PEG) polymer chains linked to polypeptides or proteins by covalent bonds. By increasing the molecular mass of proteins and peptides and
To protect them from protease hydrolysis, pegylation can improve pharmacokinetics. Pegylation can reduce renal clearance, thereby allowing subcutaneous administration and dispersion
It can be absorbed for a long time under restricted conditions.
Beike Nano provides a variety of linkers. Here are a few examples:
{Gly}, 2 Carbons
{Beta-Ala}, 3 Carbons
{GABA}, 4 Carbons
{Ava}, 5 Carbons
{AEA}, Aminoethoxyacetic Acid
{ANP Linker}
{Ahx}, 6 Carbons:
Fmoc-ε-Ahx-OH, or N-ε-Fmoc-ε-aminocaproic acid, or Fmoc-6-aminohexanoic acid; CAS number: 88574-06-5;
Molecular weight: 353.42 g/mol.
Studies have shown that synthesizing with Lys(Ahx) can have a better rate of return. It may be that the flexible Ahx during the synthesis process helps to make the polypeptide chain properly dissolved.
The drug compound avoids aggregation, thereby increasing the possibility of polypeptide sequence extension.
When preparing FITC-labeled peptides, either Ahx or b-Ala can be successfully used as linker. This will make the fluorescent label more stable. Through the sulfhydryl group of cysteine or lysine
Message
To protect them from protease hydrolysis, pegylation can improve pharmacokinetics. Pegylation can reduce renal clearance, thereby allowing subcutaneous administration and dispersion
It can be absorbed for a long time under restricted conditions.
Beike Nano provides a variety of linkers. Here are a few examples:
{Gly}, 2 Carbons
{Beta-Ala}, 3 Carbons
{GABA}, 4 Carbons
{Ava}, 5 Carbons
{AEA}, Aminoethoxyacetic Acid
{ANP Linker}
{Ahx}, 6 Carbons:
Fmoc-ε-Ahx-OH, or N-ε-Fmoc-ε-aminocaproic acid, or Fmoc-6-aminohexanoic acid; CAS number: 88574-06-5;
Molecular weight: 353.42 g/mol.
Studies have shown that synthesizing with Lys(Ahx) can have a better rate of return. It may be that the flexible Ahx during the synthesis process helps to make the polypeptide chain properly dissolved.
The drug compound avoids aggregation, thereby increasing the possibility of polypeptide sequence extension.
When preparing FITC-labeled peptides, either Ahx or b-Ala can be successfully used as linker. This will make the fluorescent label more stable. Through the sulfhydryl group of cysteine or lysine
FITC can be labeled at any position of the polypeptide by binding to the amino group of the amino acid.
{Mini-PEG}, 9 Carbons, CAS number: 166108-71-0; Fmoc-NH-(PEG)-COOH, or Fmoc-8-amino-3,6-dioxaoctanoic
acid; Molecular weight: 385.42 g/mol; C21H23NO6
{Mini-PEG2}, 13 Carbons, CAS number: 867062-95-1; Fmoc-NH-(PEG)2-COOH, or
Fmoc-12-amino-4,7,10-trioxadodecanoic acid; Molecular weight: 443.5 g/mol; C24H29NO7
{Mini-PEG3}, 16 Carbons, CAS number: 557756-85-1; Fmoc-NH-(PEG)3-COOH,
or Fmoc-15-amino-4,7,10,13-tetraoxapentadecanoic acid; Molecular weight: 489.57 g/mol; C26H35NO8
| Warm tips: Suzhou Beike nano products are only used for scientific research, not for human body,different batches of products have different specifications and performance |
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